Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-Old

AG056519

By 2050 there will be 8.5 million individuals aged 90+ in the US yet very little is known about brain aging beyond age 90 in ethnic minorities nor the role of early life influences on risk of very late-onset dementia. The Kaiser multiphasic study participants age 90+ offer an unprecedented and fleeting opportunity to evaluate 50 years of information and understand the lifecourse story of dementia and brain aging in a racially diverse oldest-old cohort. This study will redefine our knowledge of dementia and brain pathology in the oldest-old, provide new insights into early life risk and protective factors, uncover etiological underpinnings, and provide a framework for future studies of prevention of late-onset dementia and cognitive impairment in a multiethnic cohort.